AF-353 ( Ro-4)
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
CAS: 865305-30-2
Molecular Formula: C14H17IN4O2
AF-353 ( Ro-4) - Names and Identifiers
AF-353 ( Ro-4) - Physico-chemical Properties
| Molecular Formula | C14H17IN4O2 |
| Molar Mass | 400.21 |
| Density | 1.619±0.06 g/cm3(Predicted) |
| Boling Point | 510.2±60.0 °C(Predicted) |
| pKa | 6.89±0.10(Predicted) |
| Storage Condition | 2-8 ℃, dark |
AF-353 ( Ro-4) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.499 ml | 12.493 ml | 24.987 ml |
| 5 mM | 0.5 ml | 2.499 ml | 4.997 ml |
| 10 mM | 0.25 ml | 1.249 ml | 2.499 ml |
| 5 mM | 0.05 ml | 0.25 ml | 0.5 ml |
Last Update：2024-01-02 23:10:35
AF-353 ( Ro-4) - Reference Information
| biological activity | AF-353 (Ro-4), selective and orally bioavailable antagonists of P2X3 receptor and P2X2/3 receptor have pIC50 values of 8.06, 8.05 and 7.41 for human P2X3, rat P2X3 and human P2X2/3, respectively. |
| Target | TargetValue hP2X3 (Cell-free assay) 8.06(pIC50) rP2X3 (Cell-free assay) 8.05(pIC50) hP2X2/3 (Cell-free assay) 7.41(pIC50) |
| Target | Value |
| hP2X3 (Cell-free assay) | 8.06(pIC50) |
| rP2X3 (Cell-free assay) | 8.05(pIC50) |
| hP2X2/3 (Cell-free assay) | 7.41(pIC50) |
| Use | a p2x3 receptor antagonist. AF353 is a P2X3 receptor antagonist. Antagonism of the P2X3 receptor is one of the potential therapeutic strategies for the management of neuropathic pain because P2X3 receptors are predominantly localized on small to medium diameter C- and Aδ-fiber primary afferent neurons, which are related to the pain-sensing system. |
Last Update：2024-04-09 21:04:16
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Product Name: 5-(5-Iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine Request for quotationCAS: 865305-30-2
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Product Name: 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Visit Supplier Webpage Request for quotationCAS: 865305-30-2
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